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Impact of taxane-based chemotherapeutics on male reproductive function

Charvi Kanodia

Charvi Kanodia Edinburgh Medical School, University of Edinburgh, UK

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Michael P Rimmer

Michael P Rimmer MRC Centre for Reproductive Health, Institute of Regeneration and Repair, University of Edinburgh, UK

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Kathleen Duffin

Kathleen Duffin Biomedical Sciences, University of Edinburgh, UK

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Rod T Mitchell

Rod T Mitchell MRC Centre for Reproductive Health, Institute of Regeneration and Repair, University of Edinburgh, UK

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Lay summary

Men and boys with cancer treated with chemotherapy are known to have reduced fertility following their treatment. This is because some chemotherapy drugs can damage the cells in the testicles that make sperm. This study found there is limited information available on the effect of one group of chemotherapy drugs, called taxanes, on testicular function and fertility. More studies are needed to aid clinicians in advising patients on how this taxane-based chemotherapy may affect their future fertility.