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Soo Young Baik Discovery and Translational Sciences Department, Leeds Institute of Cardiovascular and Metabolic Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom

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Alisha Maini Discovery and Translational Sciences Department, Leeds Institute of Cardiovascular and Metabolic Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom

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Haidee Tinning Discovery and Translational Sciences Department, Leeds Institute of Cardiovascular and Metabolic Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom

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Dapeng Wang LeedsOmics, University of Leeds, Leeds, United Kingdom
Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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Daman J Adlam Faculty of Biology, Medicine and Health, Division of Developmental Biology and Medicine, Maternal and Fetal Health Research Centre, School of Medical Sciences, Saint Mary’s Hospital, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK
Maternal and Fetal Health Research Centre, Saint Mary’s Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, UK

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Peter T Ruane Faculty of Biology, Medicine and Health, Division of Developmental Biology and Medicine, Maternal and Fetal Health Research Centre, School of Medical Sciences, Saint Mary’s Hospital, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK
Maternal and Fetal Health Research Centre, Saint Mary’s Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, UK

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Niamh Forde Discovery and Translational Sciences Department, Leeds Institute of Cardiovascular and Metabolic Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom

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glutathione on oxidative stress and infertility . JBRA Assisted Reproduction 22 61 – 66 . ( https://doi.org/10.5935/1518-0557.20180003 ) Agarwal A Gupta S & Sharma RK 2005 Role of oxidative stress in female reproduction . Reproductive Biology and

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Chris R Burke DairyNZ Ltd., Hamilton, New Zealand

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John R Roche DairyNZ Ltd., Hamilton, New Zealand

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Robert P Millar Centre for Neuroendocrinology, Department of Immunology, University of Pretoria, Gezina, Pretoria, South Africa

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Iain J Clarke University of Monash, Clayton, Victoria, Australia

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Introduction Prolonged postpartum anovulation is a major cause of infertility in dairy cattle, particularly for seasonal production systems reliant on maintaining a 365-day calving interval ( Fielden et al. 1973 ). While there are

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Katja Hummitzsch Robinson Research Institute, School of Biomedicine, The University of Adelaide, South Australia, Australia.

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Jasmine E Kelly Robinson Research Institute, School of Biomedicine, The University of Adelaide, South Australia, Australia.

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Nicholas Hatzirodos Robinson Research Institute, School of Biomedicine, The University of Adelaide, South Australia, Australia.

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Wendy M Bonner Robinson Research Institute, School of Biomedicine, The University of Adelaide, South Australia, Australia.

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Feng Tang Robinson Research Institute, School of Biomedicine, The University of Adelaide, South Australia, Australia.

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Hugh H Harris Department of Chemistry, The University of Adelaide, South Australia, Australia.

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Raymond J Rodgers Robinson Research Institute, School of Biomedicine, The University of Adelaide, South Australia, Australia.
Adelaide Health and Medical Sciences Building, The University of Adelaide, South Australia, Australia

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Chattopadhyay R Chakravarty B & Chaudhury K 2013 Oxidative status in granulosa cells of infertile women undergoing IVF . Systems Biology in Reproductive Medicine 59 91 – 98 . ( https://doi.org/10.3109/19396368.2012.743197 ) Kodaman PH Aten RF

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Edwina F Lawson Priority Research Centre for Reproductive Science, University of Newcastle, Callaghan, New South Wales, Australia

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Christopher G Grupen Sydney School of Veterinary Science, Faculty of Science, University of Sydney, Camden, New South Wales, Australia

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Mark A Baker Priority Research Centre for Reproductive Science, University of Newcastle, Callaghan, New South Wales, Australia

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R John Aitken Priority Research Centre for Reproductive Science, University of Newcastle, Callaghan, New South Wales, Australia

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Aleona Swegen Priority Research Centre for Reproductive Science, University of Newcastle, Callaghan, New South Wales, Australia
Nuffield Department of Women’s and Reproductive Health, University of Oxford, Oxford, UK

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Charley-Lea Pollard Sydney School of Veterinary Science, Faculty of Science, University of Sydney, Camden, New South Wales, Australia

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Zamira Gibb Priority Research Centre for Reproductive Science, University of Newcastle, Callaghan, New South Wales, Australia

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9 1066 . ( https://doi.org/10.3389/fphys.2018.01066 ) Baker MA Aitken RJ 2005 Reactive oxygen species in spermatozoa: methods for monitoring and significance for the origins of genetic disease and infertility . Reproductive Biology and

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Michael P Rimmer MRC Centre for Reproductive Health, Queens Medical Research Institute, University of Edinburgh, Edinburgh, UK

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Christopher D Gregory Centre for Inflammation Research, Queens Medical Research Institute, University of Edinburgh, Edinburgh, UK

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Rod T Mitchell MRC Centre for Reproductive Health, Queens Medical Research Institute, University of Edinburgh, Edinburgh, UK

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Research Group 2017 Semen proteomics and male infertility . Journal of Proteomics 162 125 – 134 . ( https://doi.org/10.1016/j.jprot.2016.08.018 ) 27576136 Johnstone RM ADAM M Hammond JR Orr L Turbide C 1987 Vesicle formation during

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Thomas M Rawlings Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, UK

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Komal Makwana Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, UK

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Maria Tryfonos Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, UK

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Emma S Lucas Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, UK
Centre for Early Life, Warwick Medical School, University of Warwick, Coventry, UK

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impede successful pregnancy. Endometriosis is an endometrial disorder characterised by the ectopic growth of endometrial tissue. Endometriosis is associated with infertility and affects 10% of women of reproductive age. The aetiology and

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Agnes Stefansdottir Biomedical Sciences, University of Edinburgh, Edinburgh, UK

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Magda Marečková Biomedical Sciences, University of Edinburgh, Edinburgh, UK

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Magdalena Matkovic Biomedical Sciences, University of Edinburgh, Edinburgh, UK

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Caroline M Allen School of Life Sciences, University of Glasgow, Glasgow, UK

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Norah Spears Biomedical Sciences, University of Edinburgh, Edinburgh, UK

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smoking, nicotine and pregnancy . International Journal of Clinical Pharmacology and Therapeutics 37 417 – 427 . Hoyer PB & Keating AF 2014 Xenobiotic effects in the ovary: temporary versus permanent infertility . Expert Opinion on Drug

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Velez Carolina Faculty of Veterinary Science, National University of La Pampa (UNLPam), Argentina
National Scientific and Technical Research Council of Argentina (CONICET), Argentina

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Clauzure Mariangeles Faculty of Veterinary Science, National University of La Pampa (UNLPam), Argentina
National Scientific and Technical Research Council of Argentina (CONICET), Argentina

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Williamson Delia Faculty of Veterinary Science, National University of La Pampa (UNLPam), Argentina

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Garcia Monica Faculty of Veterinary Science, National University of La Pampa (UNLPam), Argentina

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Koncurat Mirta Faculty of Veterinary Science, National University of La Pampa (UNLPam), Argentina

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Barbeito Claudio National Scientific and Technical Research Council of Argentina (CONICET), Argentina
Laboratory of Descriptive, Comparative and Experimental Histology and Embriology (LHYEDEC). Faculty of Veterinary Science, National University of La Plata (UNLP), Argentina

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Ali MS & Atef AM 2017 AlphaVBeta3 integrin expression within uterine endometrium in unexplained infertility: A prospective cohort study . BMC Women’s Health 17 90 . ( https://doi.org/10.1186/S12905-017-0438-3 ) 28950833 Erikson DW Burghardt

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Christina M Merkley Department of Animal Science, North Carolina State University, Raleigh, North Carolina, USA

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Allison N Renwick Department of Animal Science, North Carolina State University, Raleigh, North Carolina, USA

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Sydney L Shuping Department of Animal Science, North Carolina State University, Raleigh, North Carolina, USA

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KaLynn Harlow Department of Animal Science, North Carolina State University, Raleigh, North Carolina, USA

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Jeffrey R Sommer Department of Animal Science, North Carolina State University, Raleigh, North Carolina, USA

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Casey C Nestor Department of Animal Science, North Carolina State University, Raleigh, North Carolina, USA

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kisspeptin, neurokinin B (NKB) is also essential for puberty, as loss-of-function mutations in the genes encoding NKB or its receptor, neurokinin 3 receptor (NK3R), result in failure of pubertal progression and infertility in humans ( Topaloglu et al. 2009

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J M Roach Comparative Biomedical Sciences, Royal Veterinary College, Hawkshead Lane, Hatfield, UK

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J C Arango-Sabogal Pathobiology and Population Sciences, Royal Veterinary College, Hawkshead Lane, Hatfield, UK

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K C Smith Pathobiology and Population Sciences, Royal Veterinary College, Hawkshead Lane, Hatfield, UK

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A K Foote Rossdales Laboratories, Newmarket, UK

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K L Verheyen Pathobiology and Population Sciences, Royal Veterinary College, Hawkshead Lane, Hatfield, UK

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A M de Mestre Comparative Biomedical Sciences, Royal Veterinary College, Hawkshead Lane, Hatfield, UK

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factors associated with reproductive efficiency, conception and foaling have been reported, along with multiple studies identifying those associated specifically with EPLs. Despite the significant differences in underlying causes of infertility in the mare

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