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Bhorika Aggarwal Reproductive Medicine Research Group, School of Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK

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Amanda L Evans Human Fertilisation and Embryology Authority (HFEA), London, UK

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Howard Ryan Human Fertilisation and Embryology Authority (HFEA), London, UK

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Sarah J Martins da Silva Reproductive Medicine Research Group, School of Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK

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Intracytoplasmic sperm injection (ICSI) is highly effective for male factor infertility. However, its use for non-male factor infertility has increased dramatically worldwide in the last 2 decades despite little evidence demonstrating

Article Type:
Brief Report
DOI:
https://doi.org/10.1530/RAF-20-0059
Volume/Issue:
Volume 2: Issue 1
Open access
Iman Al-Saleh Environmental Health Program, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

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Serdar Coskun Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

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Reem Al-Rouqi Environmental Health Program, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

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Tahreer Al-Rajudi Environmental Health Program, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

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Chafica Eltabache Environmental Health Program, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

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Mai Abduljabbar Environmental Health Program, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

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Saad Al-Hassan Reproductive Medicine Unit, Department of Obstetrics and Gynecology, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

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neurodegenerative, cardiovascular, metabolic disorders, and cancer ( Raghunath et al. 2018 ). The role of ROS in the etiology of male and female infertility has also been reported ( Agarwal et al. 2012 a , 2014 ). Some of the factors that have been implicated in

Article Type:
Research Article
Collections:
Clinical research and reviews
DOI:
https://doi.org/10.1530/RAF-20-0062
Volume/Issue:
Volume 2: Issue 2
Open access
Jason Mak Acute Gynaecology, Early Pregnancy and Advanced Endosurgery Unit, Nepean Hospital, Sydney Medical School Nepean, University of Sydney, Sydney, New South Wales, Australia

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Mathew Leonardi Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada

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George Condous Acute Gynaecology, Early Pregnancy and Advanced Endosurgery Unit, Nepean Hospital, Sydney Medical School Nepean, University of Sydney, Sydney, New South Wales, Australia

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and/or infertility whether pathology is identified or not. Argument 1: diagnostic laparoscopy is safe Overall, laparoscopy is a low-risk procedure. A Cochrane review of entry techniques which included 57 studies and 9865 participants noted that

Article Type:
Article Commentary
Collections:
Endometriosis
DOI:
https://doi.org/10.1530/RAF-21-0117
Volume/Issue:
Volume 3: Issue 3
Open access
B Ogunlade Behavioral and Aging Lab, Human Anatomy Department, Federal University of Technology Akure, Ondo State, Nigeria

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S C Gbotolorun Anatomy Department, University of Lagos, Lagos, Nigeria

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O A Adedotun Behavioral and Aging Lab, Human Anatomy Department, Federal University of Technology Akure, Ondo State, Nigeria

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K Iteire Anatomy Department, University of Medical Sciences, Ondo City, Ondo State, Nigeria

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J Adejayi Behavioral and Aging Lab, Human Anatomy Department, Federal University of Technology Akure, Ondo State, Nigeria

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Introduction Infertility in males refers to a man’s failure to achieve conception in a fertile female ( Olooto 2012 ). Male infertility is frequently due to sperm and semen quality defects ( Cooper et al. 2010 ). It is estimated that 60% of

Article Type:
Research Article
DOI:
https://doi.org/10.1530/RAF-22-0045
Volume/Issue:
Volume 3: Issue 3
Open access
Caroline M Allen Biomedical Sciences, University of Edinburgh, Edinburgh, UK

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Federica Lopes MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK

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Rod T Mitchell MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK

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Norah Spears Biomedical Sciences, University of Edinburgh, Edinburgh, UK

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Children undergoing chemotherapy to treat childhood cancers are at risk of infertility in adulthood due to drug cytotoxicity ( Allen et al. 2018 ). The development of fertility preservation strategies is therefore vital, particularly for

Article Type:
Brief Report
DOI:
https://doi.org/10.1530/RAF-21-0042
Volume/Issue:
Volume 2: Issue 4
Open access
L B P M Stevens Brentjens Department of Obstetrics and Gynaecology, Maastricht University Medical Centre+, Maastricht, The Netherlands
GROW School for Oncology and Reproduction, Maastricht University, Universiteitssingel, Maastricht, The Netherlands

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D Obukhova GROW School for Oncology and Reproduction, Maastricht University, Universiteitssingel, Maastricht, The Netherlands
Department of Clinical Genetics, Maastricht University Medical Centre (MUMC+), Maastricht, The Netherlands

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B Delvoux Department of Obstetrics and Gynaecology, Maastricht University Medical Centre+, Maastricht, The Netherlands
GROW School for Oncology and Reproduction, Maastricht University, Universiteitssingel, Maastricht, The Netherlands

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J E den Hartog Department of Obstetrics and Gynaecology, Maastricht University Medical Centre+, Maastricht, The Netherlands
GROW School for Oncology and Reproduction, Maastricht University, Universiteitssingel, Maastricht, The Netherlands

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B N Bui Department of Gynaecology & Reproductive Medicine, University Medical Centre Utrecht, Heidelberglaan, Utrecht, The Netherlands

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F Mol Centre for Reproductive Medicine, Reproduction and Development, Amsterdam University Medical Centre, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands

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J P de Bruin Department of Obstetrics and Gynaecology, Jeroen Bosch Hospital, Henri Dunantstraat, Hertogenbosch, The Netherlands

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D Besselink Department of Obstetrics and Gynaecology, Radboud University Medical Centre, Geert Grooteplein Zuid, Nijmegen, The Netherlands

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G Teklenburg Isala Fertility Clinic, Isala Hospital, Dokter van Heesweg, Zwolle, The Netherlands

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F Morgan Department of Complex Tissue Regeneration, MERLN Institute, Maastricht University, Maastricht, The Netherlands

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M Baker Department of Complex Tissue Regeneration, MERLN Institute, Maastricht University, Maastricht, The Netherlands

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F J M Broekmans Department of Gynaecology & Reproductive Medicine, University Medical Centre Utrecht, Heidelberglaan, Utrecht, The Netherlands

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R J T van Golde Department of Obstetrics and Gynaecology, Maastricht University Medical Centre+, Maastricht, The Netherlands
GROW School for Oncology and Reproduction, Maastricht University, Universiteitssingel, Maastricht, The Netherlands

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M Zamani Esteki GROW School for Oncology and Reproduction, Maastricht University, Universiteitssingel, Maastricht, The Netherlands
Department of Clinical Genetics, Maastricht University Medical Centre (MUMC+), Maastricht, The Netherlands
Division of Obstetrics and Gynaecology, Department of Clinical Science, Intervention & Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden

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A Romano Department of Obstetrics and Gynaecology, Maastricht University Medical Centre+, Maastricht, The Netherlands
GROW School for Oncology and Reproduction, Maastricht University, Universiteitssingel, Maastricht, The Netherlands

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fresh and frozen embryos were transferred but which did not result in clinical pregnancy, were included. Women could have primary infertility, i.e. no pregnancy in the past, or secondary infertility, i.e. women who were pregnant (regardless of pregnancy

Article Type:
Research Article
DOI:
https://doi.org/10.1530/RAF-23-0065
Volume/Issue:
Volume 4: Issue 4
Open access
Tamar Matitashvili Department of Obstetrics and Gynecology, The Jones Institute for Reproductive Medicine, Eastern Virginia Medical School, Norfolk, Virginia, USA

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Seifeldin Sadek Department of Obstetrics and Gynecology, The Jones Institute for Reproductive Medicine, Eastern Virginia Medical School, Norfolk, Virginia, USA

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Gerard Celia Department of Obstetrics and Gynecology, The Jones Institute for Reproductive Medicine, Eastern Virginia Medical School, Norfolk, Virginia, USA

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). Couples with the following diagnosis of infertility were included: male factor, unexplained, tubal factor, ovulatory dysfunction, endometriosis and diminished ovarian reserve. Eventually, 493 patients were enrolled in the study and their records were

Article Type:
Research Article
DOI:
https://doi.org/10.1530/RAF-22-0006
Volume/Issue:
Volume 3: Issue 2
Open access
Heidy Kaune Laboratory of Reproduction, Centre for Biomedical Research, Faculty of Medicine, Universidad Diego Portales, Santiago, Chile
Program of Ethics and Public Policies in Human Reproduction, Universidad Diego Portales, Santiago, Chile

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Juan F Montiel Laboratory of Integrative Neuroscience, Centre for Biomedical Research, Faculty of Medicine, Universidad Diego Portales, Santiago, Chile

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Mark Fenwick Academic Unit of Reproductive and Developmental Medicine, University of Sheffield, Sheffield, UK

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Suzannah A Williams Nuffield Department of Women’s and Reproductive Health, Women’s Centre, John Radcliffe Hospital, University of Oxford, Oxford, UK

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, ultimately, fertility. The fact that DM females switch their phenotype from fertile to infertile in a narrow timeframe constitutes a remarkable opportunity to study the dynamics behind the regulation of fertility by the oocyte. Several genes implicated in

Article Type:
Research Article
DOI:
https://doi.org/10.1530/RAF-22-0036
Volume/Issue:
Volume 3: Issue 3
Open access
Evangeline R Walker Department of Reproductive Medicine, Old Saint Mary’s Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK

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Mollie McGrane Maternal and Fetal Health Research Centre, Division of Developmental Biology and Medicine, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK
Maternal and Fetal Health Research Centre, Saint Mary’s Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK

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John D Aplin Maternal and Fetal Health Research Centre, Division of Developmental Biology and Medicine, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK
Maternal and Fetal Health Research Centre, Saint Mary’s Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK

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Daniel R Brison Department of Reproductive Medicine, Old Saint Mary’s Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK
Maternal and Fetal Health Research Centre, Division of Developmental Biology and Medicine, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK
Maternal and Fetal Health Research Centre, Saint Mary’s Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK

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Peter T Ruane Maternal and Fetal Health Research Centre, Division of Developmental Biology and Medicine, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK
Maternal and Fetal Health Research Centre, Saint Mary’s Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK

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infertility among the symptoms of non-malignant conditions including endometriosis, adenomyosis and fibroids ( Driva et al. 2022 ). Recurrent implantation failure after ART treatment has also been postulated to be at least partly caused by endometrial

Article Type:
Research Article
DOI:
https://doi.org/10.1530/RAF-22-0115
Volume/Issue:
Volume 4: Issue 3
Open access
Bonnie Grant Department of Endocrinology and Metabolism, Barts Health NHS Trust, West Smithfield, London

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Anjali Pradeep Section of Investigative Medicine, Imperial College London, Commonwealth Building, Hammersmith Hospital, Du Cane Road, London

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Suks Minhas Department of Urology, Charing Cross Hospital, Fulham Palace Road, London

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Waljit S Dhillo Section of Investigative Medicine, Imperial College London, Commonwealth Building, Hammersmith Hospital, Du Cane Road, London

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Richard Quinton Department of Endocrinology, Diabetes & Metabolism, Newcastle-upon-Tyne Hospitals NHS Foundation Trust & Translational & Clinical Research Institute, University of Newcastle-upon-Tyne, UK

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Channa N Jayasena Section of Investigative Medicine, Imperial College London, Commonwealth Building, Hammersmith Hospital, Du Cane Road, London

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negative feedback on gonadotrophin-releasing hormone secretion. AAS cessation causes hypogonadism, often persisting for months to years ( Kanayama et al. 2015 , Shankara-Narayana et al. 2020 ), and commonly causes sexual dysfunction, infertility

Article Type:
Letter
DOI:
https://doi.org/10.1530/RAF-22-0097
Volume/Issue:
Volume 4: Issue 1
Open access