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Sarah Simko Department of Obstetrics and Gynecology, Adventist Health White Memorial Medical Center, Los Angeles, California, USA

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Kelly N Wright Division of Minimally Invasive Gynecologic Surgery, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California, USA

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Background Endometriosis affects 10% of women of reproductive age and nearly 90% of women with chronic pelvic pain and infertility ( Lorusso et al. 2021 ). It is defined as the presence of endometrial-like tissue outside the uterus. The most

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Lauren R Alesi Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia

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Quynh-Nhu Nguyen Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia
Paediatric Integrated Cancer Service, VIC, Australia

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Jessica M Stringer Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia

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Amy L Winship Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia

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Karla J Hutt Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia

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ovarian function, fertility and endocrine health has become a prominent issue. In fact, between 40% and 80% of female cancer survivors experience infertility post-treatment ( Stern et al. 2006 , Knapp et al. 2011 ). Moreover, many patients report this

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Kei Odawara Obstetrics and Gynecology in the Department of Surgery, Showa University, Shinagawa-ku, Tokyo, Japan
Obstetrics and Gynecology, Showa University, Shinagawa-ku, Tokyo, Japan
Fertility Clinic Tokyo, Shibuya-ku, Tokyo, Japan

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Ryosuke Akino Obstetrics and Gynecology in the Department of Surgery, Showa University, Shinagawa-ku, Tokyo, Japan

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Akihiko Sekizawa Obstetrics and Gynecology in the Department of Surgery, Showa University, Shinagawa-ku, Tokyo, Japan

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Miwa Sakamoto Obstetrics and Gynecology, Showa University, Shinagawa-ku, Tokyo, Japan

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Seo Yuriko Fertility Clinic Tokyo, Shibuya-ku, Tokyo, Japan

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Kanako Tanaka Fertility Clinic Tokyo, Shibuya-ku, Tokyo, Japan

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Mutsumi Mikashima Fertility Clinic Tokyo, Shibuya-ku, Tokyo, Japan

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Masami Suzuki Fertility Clinic Tokyo, Shibuya-ku, Tokyo, Japan

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Yasushi Odawara Fertility Clinic Tokyo, Shibuya-ku, Tokyo, Japan

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reproductive medicine, including tubal infertility patients and male infertility patients. Even if a healthy embryo is obtained by egg collection, there are many cases wherein implantation does not occur, and the pregnancy reaction becomes positive after

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Tarimoboere Agbalalah Department of Anatomy, Faculty of Basic Medical Sciences, Baze University, Abuja, Nigeria
Department of Medical Biotechnology, National Biotechnology Development Agency, Abuja, Nigeria

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Faith Owabhel Robert Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK

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Emmanuel Amabebe Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK

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SCD and the consequences of vitamin B12 deficiency on female infertility, fertility and pregnancy outcomes, as well as potential mechanisms contributing to poor reproductive outcomes in SCD. No restrictions were placed on publication dates, and only

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Francesca Hearn-Yeates EXPPECT Edinburgh and Centre for Reproductive Health, University of Edinburgh, Institute for Regeneration and Repair, Edinburgh, UK

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Andrew W Horne EXPPECT Edinburgh and Centre for Reproductive Health, University of Edinburgh, Institute for Regeneration and Repair, Edinburgh, UK

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Siobhain M O’Mahony Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland
APC Microbiome Ireland, University College Cork, Cork, Ireland

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Philippa T K Saunders EXPPECT Edinburgh and Centre for Reproductive Health, University of Edinburgh, Institute for Regeneration and Repair, Edinburgh, UK

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pain (cyclical or constant) and infertility are common symptoms, patients with endometriosis often present at clinics reporting a range of other problems. These include mood disorders (anxiety, depression) and symptoms affecting their digestive system

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Camila N Ortiz Department of Basic Sciences, Ponce Health Sciences University, Ponce Research Institute, Ponce, Puerto Rico, USA

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Annelyn Torres-Reverón DHR Health Institute for Research and Development, Edinburg, Texas, USA

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Caroline B Appleyard Department of Basic Sciences, Ponce Health Sciences University, Ponce Research Institute, Ponce, Puerto Rico, USA
Department of Internal Medicine, Ponce Health Sciences University, Ponce, Puerto Rico, USA

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, dysuria, bleeding in between menstrual cycles, infertility, pelvic pain, painful defecation, and gastrointestinal symptoms ( Sinaii et al. 2008 , Mehedintu et al. 2014 ). Although some women are asymptomatic, those who experience these chronic

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Kevin Marron Sims IVF Clinic, Clonskeagh, Dublin, Ireland

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Conor Harrity RCSI University of Medicine and Health Sciences, Dublin, Ireland
Beaumont Hospital, Dublin, Ireland

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were recruited altruistically, from the same age range as the study cases in a 1:4 ratio, all of whom had at least one prior term delivery and no history of miscarriage or infertility. Fifty-eight patients with defined RPL/RIF and 15 age

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Monique Atkinson Westmead Fertility Centre, Westmead Reproduction and Perinatal Centre, Faculty of Medicine and Health, University of Sydney, Westmead Hospital, Corner of Hawkesbury and Darcy Roads, Westmead, New South Wales, Australia

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Jenny Crittenden Westmead Fertility Centre, Westmead Reproduction and Perinatal Centre, Faculty of Medicine and Health, University of Sydney, Westmead Hospital, Corner of Hawkesbury and Darcy Roads, Westmead, New South Wales, Australia

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Howard Smith Westmead Fertility Centre, Westmead Reproduction and Perinatal Centre, Faculty of Medicine and Health, University of Sydney, Westmead Hospital, Corner of Hawkesbury and Darcy Roads, Westmead, New South Wales, Australia

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Cecilia Sjoblom Westmead Fertility Centre, Westmead Reproduction and Perinatal Centre, Faculty of Medicine and Health, University of Sydney, Westmead Hospital, Corner of Hawkesbury and Darcy Roads, Westmead, New South Wales, Australia

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’s demographics, aetiology for infertility, treatment cycle details and pregnancy outcomes. Pregnancy outcomes were defined as per the European Society on Human Reproduction and Embryology (ESHRE) glossary consensus ( Zegers-Hochschild et al. 2017 ). Ethical

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Steven Reynolds Imaging Sciences, Department of Immunity, Infection and Cardiovascular Disease, University of Sheffield, Royal Hallamshire Hospital, Sheffield, UK

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Sarah J Calvert Department of Oncology and Metabolism, University of Sheffield, The Jessop Wing, Tree Root Walk, Sheffield, UK

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Stephen J Walters School of Health Related Research, University of Sheffield, Regent Court, Sheffield, UK

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Martyn N Paley Imaging Sciences, Department of Immunity, Infection and Cardiovascular Disease, University of Sheffield, Royal Hallamshire Hospital, Sheffield, UK

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Allan A Pacey Department of Oncology and Metabolism, University of Sheffield, The Jessop Wing, Tree Root Walk, Sheffield, UK

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2015 A unique view on male infertility around the globe . Reproductive Biology and Endocrinology 13 37. ( https://doi.org/10.1186/s12958-015-0032-1 ) Amaral A Paiva C Attardo Parrinello C Estanyol JM Ballesca JL Ramalho-Santos J Oliva

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Philippa T K Saunders Centre for Inflammation Research, The University of Edinburgh, Edinburgh, UK

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infertility ( Meuleman et al. 2009 ): rates in adolescents with pelvic pain range from 49% to 75% ( Shafrir et al. 2018 ). A recent review highlighted the profound negative impact on the lives of individuals with the disorder ( Missmer et al. 2021

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