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Georgina L Jones Department of Psychology, School of Humanities and Social Sciences, Leeds Beckett University, Leeds, UK

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Anne-Mairead Folan Department of Psychology, School of Humanities and Social Sciences, Leeds Beckett University, Leeds, UK

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Bob Phillips Hull-York Medical School and Centre for Reviews and Dissemination, University of York, York, UK
Paediatric Oncology, Leeds Children’s Hospital, Leeds, UK

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Richard A Anderson MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK

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Jonathan Ives Centre for Ethics in Medicine, University of Bristol, Bristol, UK

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futures There are two linked arguments to consider here, one centred on FP providing hope for a future and the other on an imagined future as a parent. Hope for a future It is well evidenced that the experience of infertility can lead to distress

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Douglas A Gibson Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK

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Frances Collins Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK

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Bianca De Leo Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK
MRC Centre for Reproductive Health, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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Andrew W Horne MRC Centre for Reproductive Health, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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Philippa T K Saunders Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK

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a hormonal treatment (H). (F) The abundance of CD14 high or CD14 low peritoneal macrophages (PMφ) did not differ between women reporting infertility (True) and those who did not (False). (G) The abundance of CD14 high or CD14 low PMφ in women

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Georgia May Department of Oncology and Metabolism, The University of Sheffield, Sheffield, UK

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1984 and provided the first guidance for the UK government on the ethics surrounding infertility treatments and research on human embryos ( Warnock 1984 ). This advised the government on the regulation of these fields, ensuring that laws passed were

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Peter Thiel Department of Obstetrics and Gynecology, University of Saskatchewan College of Medicine, Regina, Saskatchewan, Canada

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Matthew J Burke Neuropsychiatry Program, Department of Psychiatry and Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
Division of Cognitive Neurology, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA

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Philippa Bridge-Cook The Endometriosis Network Canada, Toronto, Ontario, Canada

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Mathew Leonardi Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada

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, painful intercourse, and infertility; however, non-specific symptoms often accompany these more prominent features. Treatments in the domains of medical management, surgery, and alternative management can be effective for many if used optimally but may not

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Ashlee J Medica Priority Research Centre for Reproductive Science, College of Engineering, Science and Environmental, and Faculty of Health and Medicine, University of Newcastle, Callaghan, New South Wales, Australia

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Robert J Aitken Priority Research Centre for Reproductive Science, College of Engineering, Science and Environmental, and Faculty of Health and Medicine, University of Newcastle, Callaghan, New South Wales, Australia

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Garth L Nicolson Institute for Molecular Medicine, Huntington Beach, California, USA

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Alecia R Sheridan Priority Research Centre for Reproductive Science, College of Engineering, Science and Environmental, and Faculty of Health and Medicine, University of Newcastle, Callaghan, New South Wales, Australia

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Aleona Swegen Priority Research Centre for Reproductive Science, College of Engineering, Science and Environmental, and Faculty of Health and Medicine, University of Newcastle, Callaghan, New South Wales, Australia

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Geoffry N De Iuliis Priority Research Centre for Reproductive Science, College of Engineering, Science and Environmental, and Faculty of Health and Medicine, University of Newcastle, Callaghan, New South Wales, Australia

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Zamira Gibb Priority Research Centre for Reproductive Science, College of Engineering, Science and Environmental, and Faculty of Health and Medicine, University of Newcastle, Callaghan, New South Wales, Australia

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://doi.org/10.1002/mrd.1052 ). 11468782 Collodel G Castellini C Iacoponi F Noto D Signorini C 2020 Cytosolic phospholipase A(2) and F(2) isoprostanes are involved in semen quality and human infertility: a study on leucocytospermia, varicocele and

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Shiuli Bhattacharyya UCL, Department of Medical School, London, UK

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leads to symptoms such as infertility and gynaecomastia ( Los & Ford 2023 ) ( Fukami 2023 ). Despite this, a person with Klinefelter’s syndrome is generally phenotypically male and is identified as such. A person with Turner’s syndrome (45 X0 karyotype

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Anna Lange-Consiglio Dipartimento di Medicina Veterinaria e Scienze Animali (DIVAS), Università degli Studi di Milano, Lodi, Italy

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Emanuele Capra Istituto di Biologia e Biotecnologia Agraria, Consiglio Nazionale delle Ricerche IBBA CNR, Lodi, Italy

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Noemi Monferini Dipartimento di Medicina Veterinaria e Scienze Animali (DIVAS), Università degli Studi di Milano, Lodi, Italy

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Simone Canesi Dipartimento di Medicina Veterinaria e Scienze Animali (DIVAS), Università degli Studi di Milano, Lodi, Italy

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Giampaolo Bosi Dipartimento di Medicina Veterinaria e Scienze Animali (DIVAS), Università degli Studi di Milano, Lodi, Italy

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Marina Cretich Istituto di Scienze e Tecnologie Chimiche ‘Giulio Natta’, Consiglio Nazionale delle Ricerche SCITEC-CNR, Milan, Italy

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Roberto Frigerio Istituto di Scienze e Tecnologie Chimiche ‘Giulio Natta’, Consiglio Nazionale delle Ricerche SCITEC-CNR, Milan, Italy

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Valentina Galbiati Università degli Studi di Milano, Laboratory of Toxicology (DiSFeB), Milan, Italy

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Federica Bertuzzo Intermizoo National Bull Centre of Vallevecchia, Caorle, Venezia, Italy

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Francesco Cobalchini Intermizoo National Bull Centre of Vallevecchia, Caorle, Venezia, Italy

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Fausto Cremonesi Dipartimento di Medicina Veterinaria e Scienze Animali (DIVAS), Università degli Studi di Milano, Lodi, Italy

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Bianca Gasparrini Dipartimento di Medicina Veterinaria e Produzioni Animali (DMVPA), Università degli Studi di Napoli Federico II, Naples, Italy

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( Sullivan et al. 2013 ). Given the critical contribution of EVs to gamete function, it is perhaps not surprising that their dysregulation is linked with infertility ( Stegmayr et al. 1982 , Carlsson et al. 2004 , Park et al. 2011 , Bai et al

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Ziting Chen Department of Animal Science, University of Illinois, Urbana-Champaign, Urbana, Illinois, USA
Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, Michigan, USA

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Matthew Dean Department of Animal Science, University of Illinois, Urbana-Champaign, Urbana, Illinois, USA

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Frequency of pregnancy failure Infertility is a common problem in reproductive health. Maximal fertility in women trying to conceive is only 30% per cycle ( Zinaman et al. 1996 , Bonde et al. 1998 ). Wilcox et al. (1988) found that 22

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Meihong Shi Centre de Recherche en Reproduction, Développement et Santé Intergénérationnelle, Département des Sciences Animales, Faculté des Sciences de l’Agriculture et de l’Alimentation, Pavillon INAF, Université Laval, Québec, Québec, Canada

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Marc-André Sirard Centre de Recherche en Reproduction, Développement et Santé Intergénérationnelle, Département des Sciences Animales, Faculté des Sciences de l’Agriculture et de l’Alimentation, Pavillon INAF, Université Laval, Québec, Québec, Canada

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). Meanwhile, elevated levels of NEFA were also observed in women with high BMI values and obesity ( Valckx et al. 2014 b ); and FA concentrations in FF and infertility rates were positively correlated to increased BMI. A high-fat diet can also modify NEFA

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Cecilia H M Ng School of Clinical Medicine, Division of Obstetrics and Gynaecology, Health and Medicine, UNSW, Sydney, New South Wales, Australia
Jean Hailes for Women’s Health, Melbourne, Victoria, Australia

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Andrew G Michelmore Jean Hailes for Women’s Health, Melbourne, Victoria, Australia

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Gita D Mishra School of Public Health, University of Queensland, Herston, Queensland, Australia

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Grant W Montgomery Institute of Molecular Bioscience, University of Queensland, St Lucia, Queensland, Australia

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Peter A Rogers Jean Hailes for Women’s Health, Melbourne, Victoria, Australia
Department of Obstetrics and Gynaecology, Royal Women’s Hospital, University of Melbourne, Parkville, Victoria, Australia

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Jason A Abbott School of Clinical Medicine, Division of Obstetrics and Gynaecology, Health and Medicine, UNSW, Sydney, New South Wales, Australia
Gynaecological Research and Clinical Evaluation (GRACE) Unit, Royal Hospital for Women, Randwick New South Wales, Australia

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. 2007 , Agarwal et al. 2019 , Armour et al. 2022 ). Pain and infertility significantly impacting the quality of life are the most common symptoms of endometriosis. Endometriosis has a high individual and societal burden costing an estimated $6

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