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Investigation 36 1117 – 1120 . ( https://doi.org/10.3275/9097 ) Atig F Kerkeni A Saad A Ajina M 2017 Effects of reduced seminal enzymatic antioxidants on sperm DNA fragmentation and semen quality of Tunisian infertile men . Journal of Assisted
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aging on increase DNA fragmentation was reported to be a contributing factor to the low success rate of assisted reproduction technology (ART) treatment in infertile couples ( Alvarez Sedó et al. 2017 ). Individuals should be counseled to start a
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the production of malondialdehyde (MDA) and 4-hydroxynonenal (4HNE), which oxidises the lipid membrane and causes fragmentation of both nuclear and mitochondrial DNA in sperm ( de Lamirande & Gagnon 1992 , Kodama et al. 1997 , Gomez et al. 1998