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Nicola Tempest Centre for Women’s Health Research, Department of Women’s and Children’s Health, Institute of Life Course and Medical Sciences, University of Liverpool, Member of Liverpool Health Partners, Liverpool, UK
Liverpool Women’s NHS Foundation Trust, Member of Liverpool Health Partners, Liverpool, UK
Hewitt Centre for Reproductive Medicine, Liverpool Women’s NHS Foundation Trust, Liverpool, UK

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Madeleine France-Ratcliffe Research Institute for Sport & Exercise Sciences, Liverpool John Moores University, Liverpool, UK

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Hannan Al-Lamee Centre for Women’s Health Research, Department of Women’s and Children’s Health, Institute of Life Course and Medical Sciences, University of Liverpool, Member of Liverpool Health Partners, Liverpool, UK
Hewitt Centre for Reproductive Medicine, Liverpool Women’s NHS Foundation Trust, Liverpool, UK

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Evie R Oliver Centre for Women’s Health Research, Department of Women’s and Children’s Health, Institute of Life Course and Medical Sciences, University of Liverpool, Member of Liverpool Health Partners, Liverpool, UK

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Emily E Slaine Centre for Women’s Health Research, Department of Women’s and Children’s Health, Institute of Life Course and Medical Sciences, University of Liverpool, Member of Liverpool Health Partners, Liverpool, UK

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Andrew J Drakeley Liverpool Women’s NHS Foundation Trust, Member of Liverpool Health Partners, Liverpool, UK
Hewitt Centre for Reproductive Medicine, Liverpool Women’s NHS Foundation Trust, Liverpool, UK

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Victoria S Sprung Research Institute for Sport & Exercise Sciences, Liverpool John Moores University, Liverpool, UK

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Dharani K Hapangama Centre for Women’s Health Research, Department of Women’s and Children’s Health, Institute of Life Course and Medical Sciences, University of Liverpool, Member of Liverpool Health Partners, Liverpool, UK
Liverpool Women’s NHS Foundation Trust, Member of Liverpool Health Partners, Liverpool, UK

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Introduction Infertility is defined as a reproductive disease, described as the failure to achieve a clinical pregnancy within 12 months or more, of regular unprotected sexual intercourse ( Zegers-Hochschild et al. 2009 ). Approximately one

Article Type:
Research Article
DOI:
https://doi.org/10.1530/RAF-22-0067
Volume/Issue:
Volume 3: Issue 3
Open access
Mathias Abiodun Emokpae Department of Medical Laboratory Science, School of Basic Medical Sciences, University of Benin, Benin City, Nigeria

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Somieye Imaobong Brown Department of Medical Laboratory Science, School of Basic Medical Sciences, University of Benin, Benin City, Nigeria

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of lifestyle factors in the etiology of infertility has generated a growing interest among researchers. Several authors have provided evidence of an association between lifestyle behaviors and infertility in both men and women, they include; delayed

Article Type:
Review Article
Collections:
Clinical research and reviews
DOI:
https://doi.org/10.1530/RAF-20-0046
Volume/Issue:
Volume 2: Issue 1
Open access
Madara S B Ralapanawe Tommy’s National Centre for Miscarriage Research, Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK
Fertility Centre, Lanka Hospitals Corporation Plc, Colombo, Sri Lanka

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Sugandika Lakmali Gajaweera Fertility Centre, Lanka Hospitals Corporation Plc, Colombo, Sri Lanka

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Nishendra Karunaratne Fertility Centre, Lanka Hospitals Corporation Plc, Colombo, Sri Lanka

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Malcolm James Price Institute of Applied Health Research, University of Birmingham, Birmingham, UK
NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, Birmingham, UK

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Pedro Melo Tommy’s National Centre for Miscarriage Research, Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK

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Arri Coomarasamy Tommy’s National Centre for Miscarriage Research, Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK

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Ioannis Gallos Tommy’s National Centre for Miscarriage Research, Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK

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Introduction Infertility is common, affecting one in eight couples worldwide ( ESHRE 2020 ). Assisted reproductive technology (ART), including in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI), is the mainstay

Article Type:
Research Article
DOI:
https://doi.org/10.1530/RAF-21-0116
Volume/Issue:
Volume 3: Issue 3
Open access
Francesco Saverio Ludovichetti Neurosciences Department – Dentistry Section, Università degli Studi di Padova, Padova, Italy

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Anna Giulia Signoriello Neurosciences Department – Dentistry Section, Università degli Studi di Padova, Padova, Italy

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Edoardo Alvise Gobbato Neurosciences Department – Dentistry Section, Università degli Studi di Padova, Padova, Italy

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Anna Artuso Neurosciences Department – Dentistry Section, Università degli Studi di Padova, Padova, Italy

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Edoardo Stellini Neurosciences Department – Dentistry Section, Università degli Studi di Padova, Padova, Italy

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Sergio Mazzoleni Neurosciences Department – Dentistry Section, Università degli Studi di Padova, Padova, Italy

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infertility as a disorder of the reproductive system characterized by the inability to establish a natural pregnancy following regular unprotected or targeted relationships after a period of 12 months or more. This condition affects 10–15% of women while in

Article Type:
Review Article
Collections:
Clinical research and reviews
DOI:
https://doi.org/10.1530/RAF-20-0043
Volume/Issue:
Volume 2: Issue 1
Open access
Ndivhuho B Takalani Department of Medical Biosciences, University of the Western Cape, Bellville, South Africa

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Elizabeth M Monageng Department of Medical Biosciences, University of the Western Cape, Bellville, South Africa

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Kutullo Mohlala Department of Medical Biosciences, University of the Western Cape, Bellville, South Africa

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Thomas K Monsees Department of Medical Biosciences, University of the Western Cape, Bellville, South Africa

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Ralf Henkel Department of Medical Biosciences, University of the Western Cape, Bellville, South Africa
Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK
LogixX Pharma, Theale, Reading, Berkshire, UK

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Chinyerum S Opuwari Department of Medical Biosciences, University of the Western Cape, Bellville, South Africa

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Introduction Infertility is defined as the failure to achieve pregnancy conceive following after 12 months of regular, unprotected sexual intercourse without contraceptives ( Larsen 2005 ). About 40–50% of male infertility is caused by ‘male

Article Type:
Review Article
DOI:
https://doi.org/10.1530/RAF-23-0024
Volume/Issue:
Volume 4: Issue 3
Open access
Shen Chuen Khaw NHS Tayside, Ninewells Hospital, Dundee, UK

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Zhen Zhe Wong International Medical University (IMU), Bukit Jalil, Kuala Lumpur, Federal Territory of Kuala Lumpur, Malaysia

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Richard Anderson MRC Centre for Reproductive Health, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Sarah Martins da Silva Reproductive Medicine Research Group, School of Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK

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Introduction Infertility is the inability to conceive naturally within 1 year for a sexually active couple not using contraception ( Rowe et al. 2000 , World Health Organization 2020 ). Worldwide, 15% of couples are estimated to be

Article Type:
Research Article
Collections:
Clinical research and reviews
DOI:
https://doi.org/10.1530/RAF-20-0037
Volume/Issue:
Volume 1: Issue 1
Open access
B Karavadra Norfolk & Norwich University Hospital, Obstetrics & Gynaecology, Colney Lane, Norwich, Norfolk, UK

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A Stockl University of East Anglia, Norwich Medical School, Norwich Research Park, Norwich, Norfolk, UK

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A H Balen The Leeds Teaching Hospital, Obstetrics & Gynaecology, Great George Street, Leeds, UK

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E P Morris Norfolk & Norwich University Hospital, Obstetrics & Gynaecology, Colney Lane, Norwich, Norfolk, UK

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similar messages from other studies. Vaughan et al . (2020) found that during COVID-19 infertility was the main stressor that participants were concerned about. Boivin et al . (2020) provide a very interesting insight into the coping mechanisms used

Article Type:
Research Article
Collections:
Clinical research and reviews
DOI:
https://doi.org/10.1530/RAF-20-0055
Volume/Issue:
Volume 2: Issue 1
Open access
Fabien Joao Fertilys Fertility Center, Laval, Quebec, Canada

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Cyntia Duval Fertilys Fertility Center, Laval, Quebec, Canada

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Marie-Claire Bélanger Fertilys Fertility Center, Laval, Quebec, Canada
Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CRCHUM), CHUM Research Center, Montreal, Quebec, Canada

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Julie Lamoureux Fertilys Fertility Center, Laval, Quebec, Canada

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Cheng Wei Xiao Fertilys Fertility Center, Laval, Quebec, Canada

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Senem Ates Fertilys Fertility Center, Laval, Quebec, Canada

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Moncef Benkhalifa Fertilys Fertility Center, Laval, Quebec, Canada
Université Picardie Jules Verne, Médecine et Biologie de la Reproduction et Laboratoire PERITOX, CBH-CHU Amiens Picardie, Amiens, France

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Pierre Miron Fertilys Fertility Center, Laval, Quebec, Canada

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involved in male infertility. Results showed that the seminal plasma of infertile men is more likely to contain high levels of reactive oxygen species (ROS) and lower concentrations of antioxidants ( Pasqualotto et al. 2000 , Chao et al. 2018 ). ROS

Article Type:
Research Article
DOI:
https://doi.org/10.1530/RAF-21-0005
Volume/Issue:
Volume 3: Issue 2
Open access
W Colin Duncan MRC Centre for Reproductive Health, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, UK

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Groome et al. (1996) , Duncan (2017) . In a study of endometrial secretory changes in the luteal phase, there was no evidence that infertile women had less decidualisation or more out of phase biopsies than fertile women. Indeed, there was

Article Type:
Discussion
DOI:
https://doi.org/10.1530/RAF-20-0044
Volume/Issue:
Volume 2: Issue 1
Open access
Nkoyenum Pamela Olisa Reproductive Medicine Research Group, School of Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK

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Lisa Campo-Engelstein Institute for the Medical Humanities, Preventative Medicine and Population Health, University of Texas Medical Branch, Galveston, Texas, USA

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Sarah Martins da Silva Reproductive Medicine Research Group, School of Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK

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Introduction Infertility is a global health problem. Its effects are largely unseen, yet fertility problems have a profound impact on psychological well-being and quality of life ( Nussbaum 2011 , Luk & Loke 2015 ). Wider repercussions often

Article Type:
Research Article
DOI:
https://doi.org/10.1530/RAF-22-0033
Volume/Issue:
Volume 3: Issue 3
Open access