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-mediated sperm binding ( Huszar et al. 2007 , West et al. 2022 ) and magnetic-activated cell sorting ( Nadalini et al. 2014 ). Another innovative sperm selection technique involving cumulus matrix (CM) penetration in a dish has recently been developed
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cumulus matrix, which plays a key role in in vivo fertilization ( Salustri et al . 2004 ). In the ovary, HA is to be found not only in the cumulus matrix ( Lo et al . 2019 ) but also in the theca cells and follicular fluid ( Christensen et al . 2015