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Thomas M Rawlings, Komal Makwana, Maria Tryfonos, and Emma S Lucas

human reproduction. In this review, we will explore the ontogeny of implantation modelling and propose a roadmap to application and discovery. The endometrium and implantation The mucosal lining of the uterus, the endometrium, is a complex tissue

Open access

Tsafrir S Kolatt, Yoel Shufaro, Shlomo Mashiach, Bernard Czernobilsky, Sarit Aviel-Ronen, Liat Apel-Sarid, Mazal Dahan, and Yuval Or

uterine endometrium represent specific examples where examination and monitoring of BV distribution could be of value. The case of the endometrium is unique in that sense. In the endometrial tissue, BV distribution and its subsequent evolution play a

Open access

Hannan Al-Lamee, Amy Ellison, Josephine Drury, Christopher J Hill, Andrew J Drakeley, Dharani K Hapangama, and Nicola Tempest

of gestation) ( Kolte et al. 2015 ). RPL can be described as an under-selective state of the endometrium with an inappropriately high receptivity ( Larsen et al. 2013 , Macklon & Brosens 2014 ). RRF is one of the most difficult challenges for

Open access

Marianne Watters, Catherine A Walker, Alison A Murray, Moira Nicol, and Jacqueline A Maybin

regulation of cell differentiation, proliferation, death, and metabolism ( Bartel 2004 ). Hypoxia has been shown to regulate miRNA concentrations in other tissue sites ( Kulshreshtha et al. 2007 ), but their presence in the endometrium during menstruation

Open access

Paula C C Molinari, Jarlath E Nally, and John J Bromfield

endometrium in cattle. Epithelial and stromal cells of the endometrium respond to bacterial cell wall components, including lipopolysaccharide (LPS), via the toll-like receptor family and increase the expression of pro-inflammatory mediators including IL1B

Open access

Sarah E Melford, Anthony H Taylor, and Justin C Konje

similar to the pattern of AEA production in the endometrium, where excess AEA concentrations are associated with implantation failure ( El-Talatini et al. 2009 b ). Furthermore, NO production and/or release has been shown to influence the activation of

Open access

Jennifer E Pearson-Farr, Gabrielle Wheway, Maaike S A Jongen, Patricia Goggin, Rohan M Lewis, Ying Cheong, and Jane K Cleal

Introduction The endometrium is the lining of the womb in which the embryo implants at the start of pregnancy. The regenerated endometrium becomes receptive to implantation in the period following ovulation termed the implantation window (7

Open access

Carlos H Miyashira, Fernanda Reali Oliveira, Marina Paula Andres, Julian A Gingold, and Mauricio Simões Abrão

endometriosis 36.1 ± 5.6 Cervical canal (67), posterior fornix (65), eutopic endometrium (2) Microbiome Shotgun sequencing 36 controls: infertility, myomas, ovarian borderline tumor, and teratoma Hernandes et al. (2020) Case

Open access

Philippa T K Saunders

Introduction Endometriosis is a complex, heterogeneous, chronic, incurable disorder the hallmark of which is growth of tissue ‘lesions’ that have histological features resembling the intrauterine (eutopic) endometrium outside the uterine

Open access

Samer Khoury, Einav Kadour-Peero, and Ilan Calderon

(35%) 54 (37%)  Poor 81 (32%) 40 (27%) Endometrium (mm) 9.3 ± 1.7 9.4 ± 1.7 0.61 E2 (pg/mL) (CD 12) 789 (241–10,551) 689 (95–9174) <0.0001 Progesterone (nmol/L) (CD 12) 1.6 (0.3–4.8) 1.4 (0.3–4.8) 0