human reproduction. In this review, we will explore the ontogeny of implantation modelling and propose a roadmap to application and discovery. The endometrium and implantation The mucosal lining of the uterus, the endometrium, is a complex tissue
Thomas M Rawlings, Komal Makwana, Maria Tryfonos, and Emma S Lucas
Tsafrir S Kolatt, Yoel Shufaro, Shlomo Mashiach, Bernard Czernobilsky, Sarit Aviel-Ronen, Liat Apel-Sarid, Mazal Dahan, and Yuval Or
uterine endometrium represent specific examples where examination and monitoring of BV distribution could be of value. The case of the endometrium is unique in that sense. In the endometrial tissue, BV distribution and its subsequent evolution play a
Hannan Al-Lamee, Amy Ellison, Josephine Drury, Christopher J Hill, Andrew J Drakeley, Dharani K Hapangama, and Nicola Tempest
of gestation) ( Kolte et al. 2015 ). RPL can be described as an under-selective state of the endometrium with an inappropriately high receptivity ( Larsen et al. 2013 , Macklon & Brosens 2014 ). RRF is one of the most difficult challenges for
Marianne Watters, Catherine A Walker, Alison A Murray, Moira Nicol, and Jacqueline A Maybin
regulation of cell differentiation, proliferation, death, and metabolism ( Bartel 2004 ). Hypoxia has been shown to regulate miRNA concentrations in other tissue sites ( Kulshreshtha et al. 2007 ), but their presence in the endometrium during menstruation
Paula C C Molinari, Jarlath E Nally, and John J Bromfield
endometrium in cattle. Epithelial and stromal cells of the endometrium respond to bacterial cell wall components, including lipopolysaccharide (LPS), via the toll-like receptor family and increase the expression of pro-inflammatory mediators including IL1B
Sarah E Melford, Anthony H Taylor, and Justin C Konje
similar to the pattern of AEA production in the endometrium, where excess AEA concentrations are associated with implantation failure ( El-Talatini et al. 2009 b ). Furthermore, NO production and/or release has been shown to influence the activation of
Jennifer E Pearson-Farr, Gabrielle Wheway, Maaike S A Jongen, Patricia Goggin, Rohan M Lewis, Ying Cheong, and Jane K Cleal
Introduction The endometrium is the lining of the womb in which the embryo implants at the start of pregnancy. The regenerated endometrium becomes receptive to implantation in the period following ovulation termed the implantation window (7
Carlos H Miyashira, Fernanda Reali Oliveira, Marina Paula Andres, Julian A Gingold, and Mauricio Simões Abrão
endometriosis 36.1 ± 5.6 Cervical canal (67), posterior fornix (65), eutopic endometrium (2) Microbiome Shotgun sequencing 36 controls: infertility, myomas, ovarian borderline tumor, and teratoma Hernandes et al. (2020) Case
Philippa T K Saunders
Introduction Endometriosis is a complex, heterogeneous, chronic, incurable disorder the hallmark of which is growth of tissue ‘lesions’ that have histological features resembling the intrauterine (eutopic) endometrium outside the uterine
Samer Khoury, Einav Kadour-Peero, and Ilan Calderon
(35%) 54 (37%) Poor 81 (32%) 40 (27%) Endometrium (mm) 9.3 ± 1.7 9.4 ± 1.7 0.61 E2 (pg/mL) (CD 12) 789 (241–10,551) 689 (95–9174) <0.0001 Progesterone (nmol/L) (CD 12) 1.6 (0.3–4.8) 1.4 (0.3–4.8) 0
