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Charvi Kanodia Edinburgh Medical School, University of Edinburgh, UK

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Michael P Rimmer MRC Centre for Reproductive Health, Institute of Regeneration and Repair, University of Edinburgh, UK

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Kathleen Duffin Biomedical Sciences, University of Edinburgh, UK

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Rod T Mitchell MRC Centre for Reproductive Health, Institute of Regeneration and Repair, University of Edinburgh, UK

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reproductive outcomes. Although numerous chemotherapeutics are used to treat cancers, the impact of different agents on reproductive function and fertility is poorly understood. Taxane-based chemotherapeutics are used to treat numerous cancers; however

Article Type:
Letter
DOI:
https://doi.org/10.1530/RAF-22-0134
Volume/Issue:
Volume 4: Issue 1
Open access
Lauren R Alesi Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia

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Quynh-Nhu Nguyen Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia
Paediatric Integrated Cancer Service, VIC, Australia

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Jessica M Stringer Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia

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Amy L Winship Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia

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Karla J Hutt Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia

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Mechanism of action Evidence of ovotoxicity Degree of ovotoxicity Reference Paclitaxel Taxane Induces microtubule destabilisation Single-dose (30 mg/kg) paclitaxel decreases the number of healthy antral follicles in vivo in mice

Article Type:
Review Article
DOI:
https://doi.org/10.1530/RAF-22-0123
Volume/Issue:
Volume 4: Issue 2
Open access