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Introduction The ovarian follicle is a complex unit consisting of vascularized theca cell layers, a basement membrane or basal lamina, and granulosa cells surrounding a centralized oocyte. Supporting the development and functionality of these

(CL, n  = 13), granulosa cells (GC, n  = 38), and theca cells (TC, n  = 43) and bars indicate s.e.m. ; means without a common letter are significantly different ( P < 0.05). Expression of KISS1 in ovarian follicles varied according to

cumulus matrix, which plays a key role in in vivo fertilization ( Salustri et al . 2004 ). In the ovary, HA is to be found not only in the cumulus matrix ( Lo et al . 2019 ) but also in the theca cells and follicular fluid ( Christensen et al . 2015

transcription patterns of genes related to FA metabolism in oocytes, theca cells, granulosa cells, and cumulus cells indicated that the different follicular compartments play different roles in lipid homeostasis. The β-oxidation of FA was reduced in both

was expressed by theca cells of bovine follicles throughout folliculogenesis, while in granulosa cells, IGF1 mRNA expression increased after selection ( Schams et al. 1999 ). IGF2 mRNA was mainly localised to theca cells ( Armstrong et al. 2000

oocytes, granulosa cells, and theca cells of the follicles at every stage of follicular development. In the control group, as the fo∅llicles grew, PTEN expression increas∯ed in granulosa c≛ells but decreased in the≼ oocyte cytoplasm ( Fig. 2A and B

successful implantation. Female reproductive health and function are reliant on a delicate balance of ovarian hormones that regulate the uterine menstrual cycle. The ovarian granulosa and theca cells produce and secrete estrogen to regulate the menstrual

theca cells in vitro , and experiments in ewes demonstrated that ERK inhibition reduced follicle growth and oestradiol production ( Ryan et al. 2008 ). Based on these findings, we hypothesise that the consequences of anticancer drugs on this pathway

as the granulosa cells and theca cells, and the oocyte itself. Intricate cellular communication between the oocyte and the surrounding granulosa cells determines the health and longevity of the ovary. LH and FSH are gonadotropins produced by the

profile A subset of 15 oocyte-secreted genes and 11 granulosa cell-specific genes, extracted from consensus literature, was selected from differentially expressed genes at 9-week and plotted ( Fig. 3 ). Theca cell-specific genes were not differentially