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Charvi Kanodia Edinburgh Medical School, University of Edinburgh, UK

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Michael P Rimmer MRC Centre for Reproductive Health, Institute of Regeneration and Repair, University of Edinburgh, UK

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Kathleen Duffin Biomedical Sciences, University of Edinburgh, UK

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Rod T Mitchell MRC Centre for Reproductive Health, Institute of Regeneration and Repair, University of Edinburgh, UK

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Controlled clinical study To investigate the effect of methotrexate, paclitaxel, ifosfamide, and cisplatin on fertility in poor-risk nonseminomatous germ cell tumours Testosterone, FSH, LH, sperm analysis, fatherhood 30 30 The majority of men

Article Type:
Letter
DOI:
https://doi.org/10.1530/RAF-22-0134
Volume/Issue:
Volume 4: Issue 1
Open access
Roseanne Rosario MRC Centre for Reproductive Health, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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Wanyuan Cui Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
The Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia

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Richard A Anderson MRC Centre for Reproductive Health, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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. 2005 ), there have been no clinical studies describing the impact of other EGFR inhibitors on fertility. Evidence from the adjuvant paclitaxel and trastuzumab (APT) clinical trial, a single-arm phase 2 study of 12 weeks of adjuvant paclitaxel and

Article Type:
Review Article
Collections:
Fertility preservation
DOI:
https://doi.org/10.1530/RAF-22-0020
Volume/Issue:
Volume 3: Issue 3
Open access
Lauren R Alesi Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia

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Quynh-Nhu Nguyen Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia
Paediatric Integrated Cancer Service, VIC, Australia

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Jessica M Stringer Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia

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Amy L Winship Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia

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Karla J Hutt Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia

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Mechanism of action Evidence of ovotoxicity Degree of ovotoxicity Reference Paclitaxel Taxane Induces microtubule destabilisation Single-dose (30 mg/kg) paclitaxel decreases the number of healthy antral follicles in vivo in mice

Article Type:
Review Article
DOI:
https://doi.org/10.1530/RAF-22-0123
Volume/Issue:
Volume 4: Issue 2
Open access