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Roberto Rodrigues da Rosa Filho Department of Animal Reproduction, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil

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Maíra Morales Brito Department of Animal Reproduction, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil

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Thaís Gomes Faustino Department of Animal Reproduction, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil

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Leticia Lima de Almeida Department of Animal Reproduction, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil

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Verônica Correia Manoel Department of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil

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Bruno Cogliati Department of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil

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Camila Infantosi Vannucchi Department of Animal Reproduction, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil

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epithelium and cells present in endometrial stroma ( Veiga et al. 2017 ). For e-NOS, the uterine tissue was divided in five cell clusters: glandular epithelium, luminal epithelium, cells present in endometrial stroma, endometrial vascular endothelium and

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Ziting Chen Department of Animal Science, University of Illinois, Urbana-Champaign, Urbana, Illinois, USA
Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, Michigan, USA

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Matthew Dean Department of Animal Science, University of Illinois, Urbana-Champaign, Urbana, Illinois, USA

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needs of the embryo change dramatically prior to and during implantation ( Hardy et al. 1989 , Gardner et al. 1993 ). To meet the changing needs of the embryo, the uterine epithelium takes nutrients from maternal circulation, potentially store or

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Velez Carolina Faculty of Veterinary Science, National University of La Pampa (UNLPam), Argentina
National Scientific and Technical Research Council of Argentina (CONICET), Argentina

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Clauzure Mariangeles Faculty of Veterinary Science, National University of La Pampa (UNLPam), Argentina
National Scientific and Technical Research Council of Argentina (CONICET), Argentina

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Williamson Delia Faculty of Veterinary Science, National University of La Pampa (UNLPam), Argentina

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Garcia Monica Faculty of Veterinary Science, National University of La Pampa (UNLPam), Argentina

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Koncurat Mirta Faculty of Veterinary Science, National University of La Pampa (UNLPam), Argentina

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Barbeito Claudio National Scientific and Technical Research Council of Argentina (CONICET), Argentina
Laboratory of Descriptive, Comparative and Experimental Histology and Embriology (LHYEDEC). Faculty of Veterinary Science, National University of La Plata (UNLP), Argentina

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the epithelial surfaces that integrate the feto–maternal interface ( Rout et al. 2004 ), the endometrial luminal epithelium and trophoblast. In mammals, integrins represent excellent markers of normal and abnormal stages of uterine receptivity and

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Mariana Rita Fiorimanti Area of Electron Microscopy, Department of Animal Pathology, School of Agronomy and Veterinary, National University of Río Cuarto, Río Cuarto, Argentina
National Scientific and Technical Research Council (CONICET), Argentina

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Andrea Lorena Cristofolini Area of Electron Microscopy, Department of Animal Pathology, School of Agronomy and Veterinary, National University of Río Cuarto, Río Cuarto, Argentina
National Scientific and Technical Research Council (CONICET), Argentina

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María José Moreira-Espinoza Institute of Cell Biology, Chair of Cell Biology, Histology and Embryology, School of Medical Science, National University of Córdoba, Ciudad Universitaria, Córdoba, Argentina

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María Belén Rabaglino National Scientific and Technical Research Council (CONICET), Argentina

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Claudio Gustavo Barbeito National Scientific and Technical Research Council (CONICET), Argentina
Laboratory of Descriptive, Comparative and Experimental Histology and Embriology, School of Veterinary Sciences, National University of La Plata, Buenos Aires, Argentina

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Cecilia Inés Merkis Area of Electron Microscopy, Department of Animal Pathology, School of Agronomy and Veterinary, National University of Río Cuarto, Río Cuarto, Argentina

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expression of mRNA for VEGFA and receptor KDR We observed positive staining of VEGFA in cells of the endometrial and chorionic epithelium, in the endothelium of maternal blood vessels, in the endothelium of fetal blood vessels and in the uterine glandular

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Jennifer E Pearson-Farr Human Development and Health, University of Southampton, Faculty of Medicine, Southampton, UK

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Gabrielle Wheway Human Development and Health, University of Southampton, Faculty of Medicine, Southampton, UK

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Maaike S A Jongen Human Development and Health, University of Southampton, Faculty of Medicine, Southampton, UK

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Patricia Goggin Biomedical Imaging Unit, Faculty of Medicine, University of Southampton, Southampton, UK

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Rohan M Lewis Human Development and Health, University of Southampton, Faculty of Medicine, Southampton, UK

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Ying Cheong Human Development and Health, University of Southampton, Faculty of Medicine, Southampton, UK
Complete Fertility Centre Southampton, Princess Anne Hospital, Division of Women and Newborn, Southampton, UK

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Jane K Cleal Human Development and Health, University of Southampton, Faculty of Medicine, Southampton, UK

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IA 1980 Atypical cilia of the human endometrial epithelium . Journal of Anatomy 131 309 – 315 . Devesa-Peiro A Sebastian-Leon P Garcia-Garcia F Arnau V Aleman A Pellicer A Diaz-Gimeno P 2020 Uterine disorders affecting female

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Hannan Al-Lamee Centre for Women’s Health Research, Department of Women’s and Children’s Health, Institute of Life Course and Medical Sciences, University of Liverpool, Member of Liverpool Health Partners, Liverpool, UK
Liverpool Women’s NHS Foundation Trust, Member of Liverpool Health Partners, Liverpool, UK
Hewitt Centre for Reproductive Medicine, Liverpool Women’s NHS Foundation Trust, Liverpool, UK

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Amy Ellison Centre for Women’s Health Research, Department of Women’s and Children’s Health, Institute of Life Course and Medical Sciences, University of Liverpool, Member of Liverpool Health Partners, Liverpool, UK

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Josephine Drury Centre for Women’s Health Research, Department of Women’s and Children’s Health, Institute of Life Course and Medical Sciences, University of Liverpool, Member of Liverpool Health Partners, Liverpool, UK

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Christopher J Hill Centre for Women’s Health Research, Department of Women’s and Children’s Health, Institute of Life Course and Medical Sciences, University of Liverpool, Member of Liverpool Health Partners, Liverpool, UK

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Andrew J Drakeley Liverpool Women’s NHS Foundation Trust, Member of Liverpool Health Partners, Liverpool, UK
Hewitt Centre for Reproductive Medicine, Liverpool Women’s NHS Foundation Trust, Liverpool, UK

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Dharani K Hapangama Centre for Women’s Health Research, Department of Women’s and Children’s Health, Institute of Life Course and Medical Sciences, University of Liverpool, Member of Liverpool Health Partners, Liverpool, UK
Liverpool Women’s NHS Foundation Trust, Member of Liverpool Health Partners, Liverpool, UK

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Nicola Tempest Centre for Women’s Health Research, Department of Women’s and Children’s Health, Institute of Life Course and Medical Sciences, University of Liverpool, Member of Liverpool Health Partners, Liverpool, UK
Liverpool Women’s NHS Foundation Trust, Member of Liverpool Health Partners, Liverpool, UK
Hewitt Centre for Reproductive Medicine, Liverpool Women’s NHS Foundation Trust, Liverpool, UK

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. ( https://doi.org/10.1093/humrep/det285 ) 10.1093/humrep/det285 Wada-Hiraike O Hiraike H Okinaga H Imamov O Barros RP Morani A Omoto Y Warner M Gustafsson JA 2006 Role of estrogen receptor beta in uterine stroma and epithelium: insights

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Kaltrina Krasniqi Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, UK

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Naomi Black Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, UK
University Hospitals Coventry and Warwickshire, Coventry, UK

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Erin J Williams MRC Centre for Reproductive Health & The Roslin Institute, University of Edinburgh, College of Medicine and Veterinary Medicine, Edinburgh, UK

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Osvaldo Bogado Pascottini Department of Internal Medicine, Reproduction and Population Medicine, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium

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Sarah Thornton Hook Norton Veterinary Group, White Hill Surgery, Hook Norton, UK

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Siobhan Quenby Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, UK
University Hospitals Coventry and Warwickshire, Coventry, UK

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Joshua Odendaal Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, UK
University Hospitals Coventry and Warwickshire, Coventry, UK

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different forms of endometritis. Clinical endometritis is characterised by uterine pus and presents with purulent or mucopurulent uterine discharge accompanied by endometrial inflammation often diagnosed via endometrial cytology ( Sheldon 2020 ). Subclinical

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Thomas M Rawlings Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, UK

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Komal Makwana Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, UK

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Maria Tryfonos Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, UK

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Emma S Lucas Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, UK
Centre for Early Life, Warwick Medical School, University of Warwick, Coventry, UK

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a luminal epithelium, in order to study sequential blastocyst attachment and invasion, as well as the incorporation of immune cells such as uterine natural killer cells to mimic tissue remodelling processes predicted to take place during implantation

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Janine Meuffels-Barkas Cryovault, Rhino Force SA NPC, Tokai, South Africa
Department of Production Animal Studies, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa

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Sandra Wilsher The Paul Mellon Laboratory, Brunswick, Newmarket, Suffolk, UK

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W R Twink Allen The Paul Mellon Laboratory, Brunswick, Newmarket, Suffolk, UK

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Cyrillus Ververs VetRepSol, Rhenen, Utrechtsestraatweg, TW, The Netherlands

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Imke Lueders Cryovault, Rhino Force SA NPC, Tokai, South Africa
Mammal Research Institute, Faculty of Natural and Agricultural Sciences, University of Pretoria, Hatfield, South Africa

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and E) and rhinoceros cow (C and F). B, bursa; B lig, broad ligament; Ce, cervix; Cl, clitoris; IC Lig, intercornuate ligament; K, kidney; M, mammary gland; O, ovary; Ov, oviduct; OvF, ovulation fossa; R, rectum; UB, urinary bladder; UC, uterine corpus

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Soo Young Baik Discovery and Translational Sciences Department, Leeds Institute of Cardiovascular and Metabolic Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom

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Alisha Maini Discovery and Translational Sciences Department, Leeds Institute of Cardiovascular and Metabolic Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom

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Haidee Tinning Discovery and Translational Sciences Department, Leeds Institute of Cardiovascular and Metabolic Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom

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Dapeng Wang LeedsOmics, University of Leeds, Leeds, United Kingdom
Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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Daman J Adlam Faculty of Biology, Medicine and Health, Division of Developmental Biology and Medicine, Maternal and Fetal Health Research Centre, School of Medical Sciences, Saint Mary’s Hospital, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK
Maternal and Fetal Health Research Centre, Saint Mary’s Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, UK

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Peter T Ruane Faculty of Biology, Medicine and Health, Division of Developmental Biology and Medicine, Maternal and Fetal Health Research Centre, School of Medical Sciences, Saint Mary’s Hospital, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK
Maternal and Fetal Health Research Centre, Saint Mary’s Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, UK

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Niamh Forde Discovery and Translational Sciences Department, Leeds Institute of Cardiovascular and Metabolic Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom

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uterine receptivity remain unclear. Conflicting results and discrepancies in methodologies between the studies may explain in part why this is the case. A series of studies from ovum donation cycles identified significantly higher spontaneous abortion

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